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2007•Emerging infectious diseasesOpen access

Loop-Mediated Isothermal Amplification for Influenza A (H5N1) Virus

Shanthi Jayawardena, Chung Yan Cheung, Ian Barr, Kwok Hung Chan, Honglin Chen, Yi Guan, Malik J. S. Peiris, Leo L. M. Poon

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Abstract

We describe a 1-step reverse-transcription loop-mediated isothermal amplification assay for detection of highly pathogenic avian influenza A (H5N1) viruses. The assay was tested by using a panel of highly pathogenic H5N1 subtypes isolated over the past 10 years and clinical specimens. The assay produced negative results for all non-H5N1 subtypes.

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What this paper is about

We describe a 1-step reverse-transcription loop-mediated isothermal amplification assay for detection of highly pathogenic avian influenza A (H5N1) viruses. The assay was tested by using a panel of highly pathogenic H5N1 subtypes isolated over the past 10 years and clinical specimens. The assay produced negative results for all non-H5N1 subtypes.

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Available abstract

We describe a 1-step reverse-transcription loop-mediated isothermal amplification assay for detection of highly pathogenic avian influenza A (H5N1) viruses. The assay was tested by using a panel of highly pathogenic H5N1 subtypes isolated over the past 10 years and clinical specimens. The assay produced negative results for all non-H5N1 subtypes.

Key concepts: Influenza A virus subtype H5N1, Loop-mediated isothermal amplification, Reverse Transcription Loop-mediated Isothermal Amplification, Virology, Highly pathogenic, Biology, Influenza A virus, Virus

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