2003•Antimicrobial Agents and ChemotherapyOpen access

Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Fu-Yu Chiang, Michael W. Climo

Abstract

The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.

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Key concepts: Linezolid, Vancomycin, Endocarditis, Staphylococcus aureus, Medicine, Methicillin-resistant Staphylococcus aureus, Antibiotics, Staphylococcal infections