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2013•The Chinese Journal of Clinical PharmacologyRequires access

Post-antibiotic effect of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus

Rui Wang

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Abstract

Objective To investigate the post-antibiotic effect(PAE) of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus(MRSA).Methods PAE of linezolid and vancomycin against MRSA was determined by plate colony counting at different concentrations(1×MIC,2×MIC,4×MIC,8×MIC) and different time points(1,2,3 h).The morphological changes of MRSA during the PAE period were observed by scanning electron microscopy.Results All strains were susceptible to linezolid and vancomycin.The PAE was greater at higher concentration and longer exposure time.There was no morphological change of MRSA during the PAE.Conclusion It was demonstrated that linezolid and vacomycin had a moderate in vitro PAE against MRSA.There was no morphological change of MRSA during the PAE.

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What this paper is about

Objective To investigate the post-antibiotic effect(PAE) of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus(MRSA).Methods PAE of linezolid and vancomycin against MRSA was determined by plate colony counting at different concentrations(1×MIC,2×MIC,4×MIC,8×MIC) and different time points(1,2,3 h).The morphological changes of MRSA during the PAE period were observed by scanning electron microscopy.Results All strains were susceptible to linezolid and vancomycin.The PAE was greater at higher concentration and longer exposure time.There was no morphological change of MRSA during the PAE.Conclusion It was demonstrated that linezolid and vacomycin had a moderate in vitro PAE against MRSA.There was no morphological change of MRSA during the PAE.

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Available abstract

Objective To investigate the post-antibiotic effect(PAE) of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus(MRSA).Methods PAE of linezolid and vancomycin against MRSA was determined by plate colony counting at different concentrations(1×MIC,2×MIC,4×MIC,8×MIC) and different time points(1,2,3 h).The morphological changes of MRSA during the PAE period were observed by scanning electron microscopy.Results All strains were susceptible to linezolid and vancomycin.The PAE was greater at higher concentration and longer exposure time.There was no morphological change of MRSA during the PAE.Conclusion It was demonstrated that linezolid and vacomycin had a moderate in vitro PAE against MRSA.There was no morphological change of MRSA during the PAE.

Key concepts: Linezolid, Vancomycin, Antibiotics, Staphylococcus aureus, Microbiology, Methicillin-resistant Staphylococcus aureus, Medicine, Biology

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Post-antibiotic effect of linezolid and vancomycin against methicillin-resistant Staphyloccus aureus — Research Paper | ScholarLens