2009•Antimicrobial Agents and ChemotherapyOpen access

GES-11, a Novel Integron-Associated GES Variant in Acinetobacter baumannii

Carole Ayoub Moubareck, Sylvie Brémont, M. C. Conroy, Patrice Courvalin, Thierry Lambert

Abstract

New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.

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Key concepts: Integron, Acinetobacter baumannii, Aztreonam, Microbiology, Plasmid, Neisseriaceae, Biology, Acinetobacter