2005•Antimicrobial Agents and ChemotherapyOpen access

Efficacy of Caspofungin against Aspergillus terreus

Francesco Barchiesi, Elisabetta Spreghini, Alfredo Santinelli, Annette W. Fothergill, Stefania Fallani, Esther Manso, Eleonora De Pisa, Daniele Giannini, Andrea Novelli, Maria Iris Cassetta, Teresita Mazzei, Michael G. Rinaldi, Giorgio Scalise

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Abstract

We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.

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Key concepts: Caspofungin, Aspergillus terreus, Aspergillus, In vivo, Fungal pathogen, Microbiology, Aspergillosis, Biology