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2006•Antimicrobial Agents and ChemotherapyOpen access

Efficacy of Caspofungin against Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans

Joel C. Bowman, George K. Abruzzo, Amy M. Flattery, Christopher John Gill, Emily T. Hickey, Ming Jo Hsu, Jennifer Nielsen Kahn, Paul Liberator, Andrew S. Misura, BARBARA ANN PELAK, T. C. Wang, Cameron M. Douglas

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Abstract

The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

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What this paper is about

The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

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Available abstract

The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

Key concepts: Caspofungin, Aspergillus terreus, Aspergillus flavus, Aspergillus nidulans, Aspergillus, Microbiology, Amphotericin B, Echinocandin

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Efficacy of Caspofungin against Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans — Research Paper | ScholarLens