2007•Clinical Cancer ResearchOpen access

Imaging Tumor Vascular Heterogeneity and Angiogenesis using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Alan Jackson, James P.B. O’Connor, Geoff J.M. Parker, Gordon C. Jayson

Abstract

This article reviews the application of dynamic contrast-enhanced magnetic resonance imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is placed on how variation in image acquisition and analysis affects the meaning and use of derived variables. We then review the potential for future developments, with particular reference to the application of dynamic contrast-enhanced magnetic resonance imaging to evaluate the heterogeneity of tumor tissues.

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Key concepts: Magnetic resonance imaging, Dynamic contrast, Angiogenesis, Contrast (vision), Dynamic contrast-enhanced MRI, Medicine, Radiology, Nuclear magnetic resonance