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Mediastinal mass following chemotherapy in patients with Ewing sarcoma and osteosarcoma

M. A. PANADERO, Juan Jesús Cruz, A. GOMEZ, E. Fonseca, María José García Sánchez, Juan Luis Garcı́a, G. Martín, Pedro L. Sánchez, Gonzalo Dueñas

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Abstract

Panadero MA, Cruz JJ, Gomez A, Fonseca E, Garcia MJ, Garcia J, Martin G, Sanchez P, Dueñas GA (Medical Oncology Department, University Hospital, Salamanca, Spain). Mediastinal mass following chemotherapy in patients with Ewing sarcoma and osteosarcoma (Case report). J Intern Med 1996; 239: 457–60. Thymic hyperplasia following combination chemotherapy for malignant disease is very uncommon in adolescents and adults. Our experience includes a thymic enlargement noted on the sequential computed tomography (CT) in three patients who were disease‐free after chemotherapy for Ewing sarcoma (2) and osteosarcoma (1). The development of an anterior mediastinal mass after successful chemotherapy does not always imply relapse of malignant disease. To prevent inappropriate treatment, the possibility of a benign aetiology must be considered.

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What this paper is about

Panadero MA, Cruz JJ, Gomez A, Fonseca E, Garcia MJ, Garcia J, Martin G, Sanchez P, Dueñas GA (Medical Oncology Department, University Hospital, Salamanca, Spain). Mediastinal mass following chemotherapy in patients with Ewing sarcoma and osteosarcoma (Case report). J Intern Med 1996; 239: 457–60. Thymic hyperplasia following combination chemotherapy for malignant disease is very uncommon in adolescents and adults. Our experience includes a thymic enlargement noted on the sequential computed tomography (CT) in three patients who were disease‐free after chemotherapy for Ewing sarcoma (2) and osteosarcoma (1). The development of an anterior mediastinal mass after successful chemotherapy does not always imply relapse of malignant disease. To prevent inappropriate treatment, the possibility of a benign aetiology must be considered.

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Available abstract

Panadero MA, Cruz JJ, Gomez A, Fonseca E, Garcia MJ, Garcia J, Martin G, Sanchez P, Dueñas GA (Medical Oncology Department, University Hospital, Salamanca, Spain). Mediastinal mass following chemotherapy in patients with Ewing sarcoma and osteosarcoma (Case report). J Intern Med 1996; 239: 457–60. Thymic hyperplasia following combination chemotherapy for malignant disease is very uncommon in adolescents and adults. Our experience includes a thymic enlargement noted on the sequential computed tomography (CT) in three patients who were disease‐free after chemotherapy for Ewing sarcoma (2) and osteosarcoma (1). The development of an anterior mediastinal mass after successful chemotherapy does not always imply relapse of malignant disease. To prevent inappropriate treatment, the possibility of a benign aetiology must be considered.

Key concepts: Medicine, Osteosarcoma, Chemotherapy, Sarcoma, Ewing's sarcoma, Mediastinal mass, Oncology, Radiology

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