2003•PubMedRequires access

Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours.

Gerold Holzer, Thomas Pfandlsteiner, H. Blahovec, Klemens Trieb, R. Kotz

Abstract

OBJECTIVE: To determine serum levels of TNF-beta and soluble TNF-R in patients with primary highly malignant bone tumours. PATIENTS AND METHODS: Sera of 27 patients with highly malignant osteosarcoma and Ewing sarcoma were taken at the time of diagnosis and analysed by ELISA. RESULTS: Both TNF-beta and sTNF-R levels were lower in sera from osteosarcoma patients as compared to those from Ewing sarcoma. In patients with high-grade osteosarcoma, but not Ewing sarcoma, high levels of TNF-beta correlated with bad response to neoadjuvant chemotherapy. CONCLUSION: In patients with high-grade osteosarcoma TNF-beta levels seem to be of predictive value and both TNF-beta and sTNF-R seem to be of diagnostic value for differentiation between high-grade osteosarcoma and Ewing sarcoma.

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Key concepts: Osteosarcoma, Sarcoma, Medicine, Ewing's sarcoma, Tumor necrosis factor alpha, Chemotherapy, Bone Sarcoma, Internal medicine