2014•Human Vaccines & ImmunotherapeuticsOpen access
Effectiveness of 10-year vaccination (2001–2010) for Hepatitis A in Tianjin, China
Zhilun Zhang, Xiang-jun Zhu, Ai-lan Shan, Zhigang Gao, Ying Zhang, Yaxing Ding, Hui Liu, WU Wei-shen, Yong Liu, Haiyan He, Xiaohua Xie, Wei-dong Xia, Chao Li, Wenti Xu, Zhiyuan Li, Hualiang Lin, Weiming Fu
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Abstract
Vaccination is an effective strategy to prevent and control the transmission of hepatitis A. Hepatitis A immunization program has been taken into effect since 2001 in Tianjin, China. This study evaluated the effectiveness of strategies in the prevention and control of hepatitis A. Data of serological survey, annual hepatitis A incidence, immunization coverage and the positive rate of hepatitis A IgG before and after the immunization program in residents under 15 years old were used to do the analysis. The results indicated that hepatitis A vaccine induced a striking decrease of hepatitis A incidence and a significant increase in the positive rate of anti-HAV IgG among the children younger than 15 years old. Hepatitis A vaccination in children was proved to be effective in the prevention and control of hepatitis A in Tianjin, China.
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