Research on Control of the Outbreak of Hepatitis A Using Inactivated Hepatitis A Vaccine

Objective To stop an epidemic of hepatitis A in Xiangshan County by mass immunization of susceptible populations with an inactivated hepatitis A vaccine and to evaluated the efficacy and safety by meet an emergency administrating the inactivated hepatitis A vaccine.Methods The study was nonrandomized,and uncontrolled.In August,2004,an outbreak of hepatitis A began in Xiangshan County,172 cases of acute symptomatic hepatitis A were reported and most of them were adolescents.For availably controlling the epidemic situation.Hepatitis A vaccine was offered to all persons in susceptible students and primary schools according to the serosurvey results.The hepatitis A epidemic current was statically analyzed from August to October.Result The endemic of hepatitis A was stopped after 15 days by an emergency administrating the inactivated hepatitis A vaccine 51305 doses.83651 doses vaccines used to emergency administrating and full administrating,one case occurred after 3 days among all subjects(in latent period before administrate),adverse events rate was 8.249/10 thousand.Conclusion This study suggested that hepatitis A vaccine could control the epidemic and can be used in breaking out of hepatitis A by administrating in meet the emergency,the vaccine was safe.