ScholarLens Back to search
2001•Nucleosides Nucleotides & Nucleic AcidsRequires access

UNEXPECTED RESULTS AND RECOURSE IN PROCESS OPTIMIZATION OF NUCLEOSIDE 3′-O-SUCCINATES

Quanlai Song, Yogesh S. Sanghvi

Open publisher page 7 citations

Abstract

An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography.

About this research paper

What this paper is about

An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography.

Why it matters

OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography.

Key concepts: Succinates, Succinic anhydride, Chemistry, Reagent, Succinic acid, Nucleoside, Organic chemistry, Biochemistry

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
UNEXPECTED RESULTS AND RECOURSE IN PROCESS OPTIMIZATION OF NUCLEOSIDE 3′-O-SUCCINATES — Research Paper | ScholarLens