2014•Bulletin of the Chemical Society of EthiopiaOpen access

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Muhammad Iqbal, Imam Bakhsh Baloch, Musa Kaleem Baloch

Abstract

Monoester of succinic acid (1-29), synthesised and characterised at our laboratory, were investigated with reference to their antifungal and antibacterial activities. The results concluded that though almost all the compounds were bioactive but the degree of activity was dependent over the substituent attached to benzyl group and order of their bioactivity was iodo > chloro > methoxy > nitro substituted monoesters against the considered microbes. KEY WORDS: Succinic anhydride, Aryl alcohols, Monoesters of succinic acid, Antifungal and antibacterial activity Bull. Chem. Soc. Ethiop. 2014, 28(1), 131-136.DOI: http://dx.doi.org/10.4314/bcse.v28i1.15

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Key concepts: Chemistry, Succinic anhydride, Succinic acid, Antifungal, Substituent, Aryl, Antibacterial activity, Nitro