2011•Chemical and Pharmaceutical BulletinOpen access

Citrinin Derivatives from the Marine-Derived Fungus Penicillium citrinum

Li Chen, Wei Liu, Xiao Hu, Kai Huang, Jiulin Wu, Qiqing Zhang

Abstract

Three new citrinin derivatives, penicitrinols C, D, and E (1-3), along with two known compounds, citrinin (4) and decarboxydihydrocitrinone (5), were isolated from Penicillium citrinum. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 3 demonstrated weak cytotoxicity against the HL-60 cell line.

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Key concepts: Citrinin, Penicillium citrinum, Chemistry, Fungus, Cytotoxicity, Stereochemistry, Mycotoxin, Penicillium