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Phototoxic Potential of Minocycline and Doxycycline

Phillip Frost

Open publisher page 119 citations

Abstract

In a double-blind study, subjects were exposed to natural sunlight after taking either of two tetracycline antibiotics or placebo capsules for one week. Mild, transient, abnormal sunburn reactions, paresthesias, or both, developed in 11 of 15 subjects who took doxycycline and in none of the subjects who took minocycline or placebo capsules. Tingling and burning of the extremities and other exposed parts was a highly sensitive indicator of abnormal reactions to sunlight.

About this research paper

What this paper is about

In a double-blind study, subjects were exposed to natural sunlight after taking either of two tetracycline antibiotics or placebo capsules for one week. Mild, transient, abnormal sunburn reactions, paresthesias, or both, developed in 11 of 15 subjects who took doxycycline and in none of the subjects who took minocycline or placebo capsules. Tingling and burning of the extremities and other exposed parts was a highly sensitive indicator of abnormal reactions to sunlight.

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OpenAlex reports 119 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In a double-blind study, subjects were exposed to natural sunlight after taking either of two tetracycline antibiotics or placebo capsules for one week. Mild, transient, abnormal sunburn reactions, paresthesias, or both, developed in 11 of 15 subjects who took doxycycline and in none of the subjects who took minocycline or placebo capsules. Tingling and burning of the extremities and other exposed parts was a highly sensitive indicator of abnormal reactions to sunlight.

Key concepts: Minocycline, Doxycycline, Medicine, Sunburn, Placebo, Phototoxicity, Tetracycline, Dermatology

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