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2013•Zhongguo quanke yixueRequires access

The Applications of Semi-synthetic Tetracycline Antibiotic in the Treatment of Multiple Sclerosis

LI Zuo-xia

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Abstract

The semi-synthetic tetracycline antibiotic is a tetracycline derivative.The present study has shown that aside from its antibiotic activities(bacteriostatic and anti-inflammatory effect),it also has non-antibiotic activities,including anti-oxidation and anti-apoptosis properties.In clinical it has been served as a neuroprotective agent for the treatment of stroke,multiple sclerosis and other acute and chronic neurological diseases.In this paper,the mechanism of semi-synthetic tetracycline antibiotics(minocycline and doxycycline) treating multiple sclerosis will be mainly reviewed.

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What this paper is about

The semi-synthetic tetracycline antibiotic is a tetracycline derivative.The present study has shown that aside from its antibiotic activities(bacteriostatic and anti-inflammatory effect),it also has non-antibiotic activities,including anti-oxidation and anti-apoptosis properties.In clinical it has been served as a neuroprotective agent for the treatment of stroke,multiple sclerosis and other acute and chronic neurological diseases.In this paper,the mechanism of semi-synthetic tetracycline antibiotics(minocycline and doxycycline) treating multiple sclerosis will be mainly reviewed.

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Available abstract

The semi-synthetic tetracycline antibiotic is a tetracycline derivative.The present study has shown that aside from its antibiotic activities(bacteriostatic and anti-inflammatory effect),it also has non-antibiotic activities,including anti-oxidation and anti-apoptosis properties.In clinical it has been served as a neuroprotective agent for the treatment of stroke,multiple sclerosis and other acute and chronic neurological diseases.In this paper,the mechanism of semi-synthetic tetracycline antibiotics(minocycline and doxycycline) treating multiple sclerosis will be mainly reviewed.

Key concepts: Minocycline, Medicine, Tetracycline, Doxycycline, Antibiotics, Multiple sclerosis, Tetracycline antibiotics, Neuroprotection

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