1974•Antimicrobial Agents and ChemotherapyOpen access

Activity of Tetracycline, Doxycycline, and Minocycline Against Methicillin-Susceptible and -Resistant Staphylococci

J. N. Minuth, T. M. Holmes, Daniel M. Musher

Abstract

Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.

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Key concepts: Minocycline, Doxycycline, Tetracycline, Microbiology, Antibacterial agent, Staphylococcus aureus, Antibiotics, Methicillin-resistant Staphylococcus aureus