2012•Journal of Enzyme Inhibition and Medicinal ChemistryOpen access

Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

Bahar Bilgin Sökmen, Gülşah Aydın, Arzu Gümüş, Şeref Karadeniz, Halil İbrahim Uğraş, Refiye Yanardağ, Ümit Çakır

Abstract

A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH·) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.

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Key concepts: Scavenging, DPPH, Antioxidant, ABTS, Chemistry, Methylene, In vitro, Organic chemistry