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1953•EndocrinologyRequires access

RESPONSE OF PREPUTIAL AND ADRENAL GLANDS OF HYPOPHYSECTOMIZED RATS TO ACTH1

M. Hess, Edward G. Rennels, John C. Finerty

Open publisher page 5 citations

Abstract

THE growth response of the preputial glands of the female rat to ACTH in adrenalectomized-ovariectomized animals indicates that these glands are subject to the direct action of this trophic hormone (Jacot and Selye, 1952). Furthermore, it has been shown that the ascorbic acid of male rat preputial glands can be depleted by stress or ACTH in acute experiments, and that these alterations in the vitamin content resemble the changes which occur in the adrenal gland following these same stimuli (Hess et al., 1952). It has been known for some time that the level of adrenal ascorbic acid is greatly reduced by hypophysectomy (Leblond and Chamorro, 1940; Bowman et al., 1940). Tyslowitz (1943) reported that the concentration of ascorbic acid in the adrenal glands gradually declines for about 18 days following the operation. Thereafter, he found that the concentration remained stabilized at about 60% of the value for intact animals.

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THE growth response of the preputial glands of the female rat to ACTH in adrenalectomized-ovariectomized animals indicates that these glands are subject to the direct action of this trophic hormone (Jacot and Selye, 1952). Furthermore, it has been shown that the ascorbic acid of male rat preputial glands can be depleted by stress or ACTH in acute experiments, and that these alterations in the vitamin content resemble the changes which occur in the adrenal gland following these same stimuli (Hess et al., 1952). It has been known for some time that the level of adrenal ascorbic acid is greatly reduced by hypophysectomy (Leblond and Chamorro, 1940; Bowman et al., 1940). Tyslowitz (1943) reported that the concentration of ascorbic acid in the adrenal glands gradually declines for about 18 days following the operation. Thereafter, he found that the concentration remained stabilized at about 60% of the value for intact animals.

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Available abstract

THE growth response of the preputial glands of the female rat to ACTH in adrenalectomized-ovariectomized animals indicates that these glands are subject to the direct action of this trophic hormone (Jacot and Selye, 1952). Furthermore, it has been shown that the ascorbic acid of male rat preputial glands can be depleted by stress or ACTH in acute experiments, and that these alterations in the vitamin content resemble the changes which occur in the adrenal gland following these same stimuli (Hess et al., 1952). It has been known for some time that the level of adrenal ascorbic acid is greatly reduced by hypophysectomy (Leblond and Chamorro, 1940; Bowman et al., 1940). Tyslowitz (1943) reported that the concentration of ascorbic acid in the adrenal glands gradually declines for about 18 days following the operation. Thereafter, he found that the concentration remained stabilized at about 60% of the value for intact animals.

Key concepts: Preputial gland, Ascorbic acid, Internal medicine, Endocrinology, Hypophysectomy, Ovariectomized rat, Adrenal gland, Corticosterone

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