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2009•Journal of the Chilean Chemical SocietyOpen access

IMPROVEMENT OF GALANGIN SOLUBILITY USING NATIVE AND DERIVATIVE CYCLODEXTRINS: AN UV-Vis AND NMR STUDY

Carolina Jullian

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Abstract

The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated.The stoichiometric ratios and stability constants describing the extent of the formation of the complexes have been determined by phase-solubility measurements; in all cases type-A L diagrams have been obtained (soluble 1:1 complexes).The results showed that the complex efficiency of βCD and its derivatives was the order: DMβCD > HPβCD > βCD.The NMR study indicate that the inclusion of galangin in the cyclodextrin nano-cavity is different depending on the type of cyclodextrin used.

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The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated.The stoichiometric ratios and stability constants describing the extent of the formation of the complexes have been determined by phase-solubility measurements; in all cases type-A L diagrams have been obtained (soluble 1:1 complexes).The results showed that the complex efficiency of βCD and its derivatives was the order: DMβCD > HPβCD > βCD.The NMR study indicate that the inclusion of galangin in the cyclodextrin nano-cavity is different depending on the type of cyclodextrin used.

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Available abstract

The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated.The stoichiometric ratios and stability constants describing the extent of the formation of the complexes have been determined by phase-solubility measurements; in all cases type-A L diagrams have been obtained (soluble 1:1 complexes).The results showed that the complex efficiency of βCD and its derivatives was the order: DMβCD > HPβCD > βCD.The NMR study indicate that the inclusion of galangin in the cyclodextrin nano-cavity is different depending on the type of cyclodextrin used.

Key concepts: Solubility, Galangin, Derivative (finance), Chemistry, Proton NMR, Ultraviolet visible spectroscopy, Materials science, Organic chemistry

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