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1994•Journal of Clinical Biochemistry and NutritionOpen access

Increased Sensitivity of Platelets from Unstable Angina Patients to Adenosine Diphosphate-Induced Aggregation.

Gomathy Viswanathan, P.T. Viswambharan NAIR

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Abstract

ADP-induced platelet aggregation of normal individuals and of patients with unstable angina were studied. Abnormalities of platelet function included increased aggregability. The ADP concentration required for half-maximal aggregation was significantly lower (4.28±0.30μM) in the unstable angina patients compared with that for normal individuals (5.24±0.15μM). The results are suggestive of platelet aggregation as a useful prognostic indicator for unstable angina.

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ADP-induced platelet aggregation of normal individuals and of patients with unstable angina were studied. Abnormalities of platelet function included increased aggregability. The ADP concentration required for half-maximal aggregation was significantly lower (4.28±0.30μM) in the unstable angina patients compared with that for normal individuals (5.24±0.15μM). The results are suggestive of platelet aggregation as a useful prognostic indicator for unstable angina.

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Available abstract

ADP-induced platelet aggregation of normal individuals and of patients with unstable angina were studied. Abnormalities of platelet function included increased aggregability. The ADP concentration required for half-maximal aggregation was significantly lower (4.28±0.30μM) in the unstable angina patients compared with that for normal individuals (5.24±0.15μM). The results are suggestive of platelet aggregation as a useful prognostic indicator for unstable angina.

Key concepts: Unstable angina, Adenosine diphosphate, Platelet aggregation, Platelet, Medicine, Internal medicine, Cardiology, Angina

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Increased Sensitivity of Platelets from Unstable Angina Patients to Adenosine Diphosphate-Induced Aggregation. — Research Paper | ScholarLens