2005•Journal of Enzyme Inhibition and Medicinal ChemistryOpen access

Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles

Gülgün Ayhan‐Kılcıgil, Canan Kuş, Tülay Çoban, Benay Can Eke, Süheyla Özbey, Mümtaz İşcan

Abstract

The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18-fold more potent than BHT (IC50 2.3 x 10(-4) M) with 1.3 x 10(-5) M and 1.2 x 10(-5) M IC50 values, respectively, by interaction of the stable DPPH free radical.

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Key concepts: Antioxidant, Chemistry, DPPH, Benzimidazole, Lipid peroxidation, Superoxide, IC50, Scavenging