ScholarLens Back to search
2010•Asian Journal of Research in ChemistryRequires access

UV-Spectrophotometric Estimation of Atorvastatin Calcium in Tablet Dosage Form.

Pandurang Dhabale, Vijay Yeshawantrao Jadhav, Chandrakant Raut

Open publisher page 3 citations

Abstract

A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of atorvastatin calcium in tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 247.5 nm. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer's law in the concentration range from 3 μg/ml to 30 μg/ml. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies. These methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

About this research paper

What this paper is about

A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of atorvastatin calcium in tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 247.5 nm. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer's law in the concentration range from 3 μg/ml to 30 μg/ml. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies. These methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

Why it matters

OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

A new, simple, specific, sensitive, accurate, precise and economical procedure for determination of atorvastatin calcium in tablet dosage form has been developed using Zero order and Second Order Derivative Method. In the proposed method, the signals of absorbance maxima were measured at 247.5 nm. The method based on the native ultraviolet absorbance maxima. The drug obeyed Beer's law in the concentration range from 3 μg/ml to 30 μg/ml. The results of analysis have been validated statistically and by recovery studies. The method shows good repeatability and recovery with % RSD is less than 2. The precision and accuracy of method were confirmed by repeatability and by recovery studies. These methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.

Key concepts: Repeatability, Absorbance, Dosage form, Chromatography, Chemistry, Atorvastatin, Biomedical engineering, Materials science

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
UV-Spectrophotometric Estimation of Atorvastatin Calcium in Tablet Dosage Form. — Research Paper | ScholarLens