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2013•Asian Journal of Pharmaceutical AnalysisRequires access

Development and Validation of Difference Spectrophotometric Method for Zotepine in Bulk and Tablet Dosage Form

Mrudula Kulkarni, Pratibha Dange, Sanjay G. Walode

Open publisher page 1 citations

Abstract

A simple, accurate and specific UV spectrophotometric method was developed and validated for the estimation of ZOT in bulk and tablet dosage form. Analyte showed the absorption maxima at 264nm in 0.1M HCl and at 235nm in 0.1M NaoH. The developed method was validated with respect to linearity, accuracy, precision and specificity. Beer's law was obeyed in the concentration range of 5-35 μg/ml having linear regression equation y=0.0461× + 0.3786 with correlation coefficient of 0.9957. Results of the analysis were validated statistically as per ICH guidelines.

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What this paper is about

A simple, accurate and specific UV spectrophotometric method was developed and validated for the estimation of ZOT in bulk and tablet dosage form. Analyte showed the absorption maxima at 264nm in 0.1M HCl and at 235nm in 0.1M NaoH. The developed method was validated with respect to linearity, accuracy, precision and specificity. Beer's law was obeyed in the concentration range of 5-35 μg/ml having linear regression equation y=0.0461× + 0.3786 with correlation coefficient of 0.9957. Results of the analysis were validated statistically as per ICH guidelines.

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Available abstract

A simple, accurate and specific UV spectrophotometric method was developed and validated for the estimation of ZOT in bulk and tablet dosage form. Analyte showed the absorption maxima at 264nm in 0.1M HCl and at 235nm in 0.1M NaoH. The developed method was validated with respect to linearity, accuracy, precision and specificity. Beer's law was obeyed in the concentration range of 5-35 μg/ml having linear regression equation y=0.0461× + 0.3786 with correlation coefficient of 0.9957. Results of the analysis were validated statistically as per ICH guidelines.

Key concepts: Dosage form, Correlation coefficient, Mathematics, Linearity, Linear regression, Analyte, Beer–Lambert law, Chromatography

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Development and Validation of Difference Spectrophotometric Method for Zotepine in Bulk and Tablet Dosage Form — Research Paper | ScholarLens