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1984•Journal of Clinical MicrobiologyOpen access

Comparison of fluorescence polarization immunoassay and bioassay of vancomycin

D J Pohlod, Louis D. Saravolatz, Margaret M. Somerville

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Abstract

Human serum samples were analyzed for vancomycin concentrations by two different methods: the fluorescence polarization immunoassay and the disk plate bioassay. Each assay method offered acceptable precision. The correlation between both assay methods was excellent (correlation coefficient = 0.985). Excluding technical time, the bioassay was the least expensive method to perform but was more labor intensive than the fluorescence polarization immunoassay.

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What this paper is about

Human serum samples were analyzed for vancomycin concentrations by two different methods: the fluorescence polarization immunoassay and the disk plate bioassay. Each assay method offered acceptable precision. The correlation between both assay methods was excellent (correlation coefficient = 0.985). Excluding technical time, the bioassay was the least expensive method to perform but was more labor intensive than the fluorescence polarization immunoassay.

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Available abstract

Human serum samples were analyzed for vancomycin concentrations by two different methods: the fluorescence polarization immunoassay and the disk plate bioassay. Each assay method offered acceptable precision. The correlation between both assay methods was excellent (correlation coefficient = 0.985). Excluding technical time, the bioassay was the least expensive method to perform but was more labor intensive than the fluorescence polarization immunoassay.

Key concepts: Bioassay, Fluorescence polarization immunoassay, Immunoassay, Chromatography, Correlation coefficient, Fluorescence, Fluorescence anisotropy, Chemistry

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