Cephalosporins induced seizures

Abstract Cephalosporin group is one of the widely used b lactam antibiotics as it has broad spectrum and relatively safe. Adverse reactions, however, are reported e.g. allergy, superinfection, and disulfiram like reaction. Anyway, cephalosporin can cause severe adverse reactions such as seizure if the drug is accumulated in the body especially in the central nervous system. Cephalosporin induced seizure may cause death in some cases. Understanding the risk factors and having a good practice guideline in using cephalosporin would promote the safe use of the drug.