Cyclooxygenenase-2 and vascular endothelial growth factor expression in cevial cancer and cervical precancerous lesions.

Objective To explore the expression of cyclooxygenenase-2(COX-2)in cervical carcinogenesis and to analyze the correlation of the expression of COX-2 and vascular endothelial growth factor(VEGF).Method COX-2 and VEGF expression were examined by S-P immunohistochemisty in 20 cases of benign cervix,26 low-grade cervical intraepithelial neoplasia(CIN;CINⅠ),28 high-grade CIN(CINⅡ / Ⅲ) and 25 cervical cancer.The correlations of COX-2,VEGF and high-risk human papillomavirus(HPV)infection were analyzed.Result Positive detection rates in normal cervix,low-grade CIN,high-grade CIN and cervical cancer for COX-2 were 0,23.08%,57.14% and 84%,respectively;for VEGF were 5%,30.77%,60.71% and 88%,respectively.COX-2 and VEGF detection rates were significantly increased in parallel to the severity of CIN and invasive disease(P0.001).COX-2 expression was statistically correlated to VEGF expression(P=0.001).The human papillomavirus(HPV)infection rates in low-grade CIN,high-grade CIN and invasive disease were 30.77%,71.43% and 100%,respectively and was statistically correlated to COX-2 expression(P=0.021).Conclusion On the basis of our findings,COX-2 expression may participate in the development and progression of cervical precancerous lesions to invasive desease and correlate with angiogenesis.COX-2 may be a potential molecular target for cervical cancer prevention and treatment.