The correlation between serum homocysteine and hs-CRP level in acute coronary syndrome patients with type 2 diabetes.

Objective To observe the levels of serum homocysteine and hs-CRP and evaluate the correlation between homocysteine and hs-CRP in acute coronary syndrome(ACS) with type 2 diabetes.Methods 60 patients with acute coronary syndrome were divided into two groups,including 12 patinets with diabetes and 25 normal controls based on their clinical situations,electrocardiogram,coronary arteriongraphy,serum Hcy,hs-CRP and C-peptide were measured.Results The levels of serum Hcy and hs-CRP were significantly increased in patients with acute coronary syndrome compared to those of control group.The serum hs-CRP levels were higher in ACS and ACS with type 2 diabetes group than control group(P0.01);Hcy was significantly higher in ACS group than control group(P0.05).But there was no difference between ACS with type 2 diabetes group and control group(P0.05).The correlation between homocysteine and hs-CRP level was positive in ACS,while there was no correlation between hs-CRP and Hcy level in ACS and ACS with type 2diabetes group(P0.05);No correlation was found between Hcy and C-peptide and insulin sensitivity index among ACS、ACS with type 2 diabetes mellitus and control group respectively.Conclusion There is a positive correlation between serum Hcy and hs-CRP,but no correlation between homocysteine,insulin sensitivity index and C-peptide was observed.