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FURTHER STUDY ON CHARACTERIZATION OF 615 MOUSE LEUKEMIC AUTOINHIBITORY ACTIVITY

吴克复, 刘黎, 王维新, 刘志宏, 应红光

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Abstract

There have been some reports on autocrine of leukemic cell lines, however, very few on leukemic negative autocrine up to date. It was demonstrated that some of leukemic cell lines could produce Tumor Necrosis Factor(TNF) and also its receptor. We have found an inhibitor from murine leukemia L7811 which could inhibit autologus leukemic cells. Later on leukemic cells from another 615 murine transplantable leukemia L615 was found to have similar autoinhibitor activit. Subsequently, it was confirmed that other T-cell

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What this paper is about

There have been some reports on autocrine of leukemic cell lines, however, very few on leukemic negative autocrine up to date. It was demonstrated that some of leukemic cell lines could produce Tumor Necrosis Factor(TNF) and also its receptor. We have found an inhibitor from murine leukemia L7811 which could inhibit autologus leukemic cells. Later on leukemic cells from another 615 murine transplantable leukemia L615 was found to have similar autoinhibitor activit. Subsequently, it was confirmed that other T-cell

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Available abstract

There have been some reports on autocrine of leukemic cell lines, however, very few on leukemic negative autocrine up to date. It was demonstrated that some of leukemic cell lines could produce Tumor Necrosis Factor(TNF) and also its receptor. We have found an inhibitor from murine leukemia L7811 which could inhibit autologus leukemic cells. Later on leukemic cells from another 615 murine transplantable leukemia L615 was found to have similar autoinhibitor activit. Subsequently, it was confirmed that other T-cell

Key concepts: Autocrine signalling, Leukemia, Cell culture, Cancer research, Tumor necrosis factor alpha, Cell, Chemistry, Biology

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