Resistance of staphylococcus and D-test analysis in nococomial infection.

Objective To investigate the resistance of staphylococcus in nocomial infection and evaluate the clinical value of inducible clindamycin resistance(D-test). Method D-test and drug resistance experiments were applied in 539 strains of staphylococci isolated from in-patients with statistical analysis.Result Of all 539 staphylococcus strains,351 strains(65.1%) were MRSA,450 strains(83.6%) were MPSE.All strains were sensitive to vancomycin.The percentage of sensitivity to β-lactamase antibiotics including amoxicillin was no more than 35%.D-test positive rate was 57.0% of which were erythromycin resistant but clindamycin sensitive.Conclusion The ratio of MRSA in staphylococcus strains is rather high.,which show character of multipdrug resisteance.D-test for detection of inducible resistance of erythromycin to clindamycin in staphylococcus strains should be checked in clinical microbiology laboratory,which could help the physicians to choose correctly the antibiotics such as macrolide and clindamycin.