Study on multimodality computed tomography imaging-based intravenous thrombolysis with rt-PA in acute ischemia stroke.

Objective To evaluate the efficiency and safety of multimodality computed tomography imaging-based intravenous thrombolysis with rt-PA in acute ischemia stroke. Method In accordance with the criterion of thrombolysis trial of National Institue of Neurological Disorders and Stroke (NINDS), 16 patients with new onset of acute ischemia stroke were scanned by multimodality computed tomography. 8 patients' corresponding test criteria were treated intravously by rt-PA 0.09 mg / kg. The National Institue of Neurological Disorders and Stroke (NINDS) scores and Barthel index were compared before and 24 h, 7d, and 30d after treatment. Result 8 patients who met the criteria were evaluated. The NIHSS scores before and 24 h, 7 d, 30 d after treatment were (12.8±5.33),(10.01± 6.69), (6.77±3.56)and (4.12±3.09), respectively. There were significant differences between before and after treatment(P0.05). The Barthel index before and 24 h, 7 d and 30 d after treatment were (20.63±8.67), (22.77± 8.96), (45.78±23.89) and (59.45±31.03), respectively. There was also significant differences between before and after treatment(P0.05). One patient died of reinfraction. Conclusion Intravenous thrombolysis with rt-PA(0.9 mg / kg) is a safe and effective treatment for patients with acute ischemia stroke after multimodal CT. The multimodal CT is helpful to those patients and may reduce the risk of bleeding after the treatment.