The Clinical Study of Thrombolysis with rt-PA in Acute Ischemic Stroke

Aim: To investigate the curative effect and complications of thrombolysis with recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke within 6 hours of symptom onset,and analyse the factors related the outcomes. Methods: 70 cases of acute cerebral infarction within 6 hours who were treated with rt-PA [52 cases with intra-venous (IV) and 18 cases with intra-arterial (IA) ] were evaluated retrospectively during 2001- 2005. We evaluate the European Stroke Scale (ESS) and the Barthel Index(BI) which were measured in two groups respectively before and after thrombolysis and following up for 3 months. Also we analyse the complications of the prognosis. Results: In the IV and IA group, the ESS scores and Barthel Index increased rapidly after thrombolysis with significant difference. The hemorrhage rates were 5.77% (IV) and 16.67% (IA). Patients who are young or with low NIHSS or high ESS score or high BI score evaluated after thrombolysis have good prognosis. Conclusion: Thrombolysis with rt-PA in acute ischemic stroke within 6 hours from the onset is relatively safe and effective.