Insight into mechanisms of reduced orthostatic performance after exposure to microgravity: comparison of ground-based and space flight data.

Since the beginning of human spaceflight, the value of understanding mechanisms of physiological adaptation to microgravity became apparent to life scientists who were interested in maintining crew health and developing countermeasures agains adverse effects of the mission. However, several characteristics associated the the logistics of spaceflight presented significant limitations to the scientific study of human adaptation to microgravity. Because space missions are so infrequent and involve minimal numbers of crewmembers, meaninful statistical analysis of data are limited. Reproducibility of results from spaceflight experiments is difficult to assess since there are few repeated space missions involving the same crewmembers. Since the emphasis of space missions is placed on operations, experiments are compromised without adequate control over various factors (e.g., time, diet, physical activities, etc.) that can impact measured responses. With the mimimal opportunity to collect spaceflight data, there is a high risk of experiments that simultaneously interfere with other experiments by the increasing demand on the crewmembers to participate in mumerous experiments proposed by multiple investigators. The technology and ability to measure physiological functions necessary to test specific hypotheses can be severely limited by physical space and power constraints of the space enviroment. Finally, technical and logistical aspects of space missions such as launch delays, extended missions, and inflight operational emergencies can significantly compromise the timing and control of experiments. These limitations have stimulated scientists to develop ground-based analogs of microgravity in an effort to investigate the effects of spaceflight on physiological function in a controlled experimental setting. The purpose of this paper is to provide a selected comparison of data collected from ground-based experiments with those obtained from spaceflight in an effort to assess the adequacy of ground analogs of actual flight for the study of human physiological adaptation to microgravity. Specifically, results from ground and spaceflight will be used to provide insight into mechanisms underlying adaptations of blood pressure regulation and reduced orthostatic performance to the microgravity environment.