CONSTITUTIONAL HEPATIC DYSFUNCTION

Case Reports1 January 1958CONSTITUTIONAL HEPATIC DYSFUNCTIONJULIUS J. CHOSEY, M.D., FLOYD M. BEMAN, M.D.JULIUS J. CHOSEY, M.D.Search for more papers by this author, FLOYD M. BEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-202 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONJaundice is ordinarily considered to be a sign of altered bilirubin metabolism. The significance of this symptom is evident when one considers the elaborate studies carried out in an attempt to clarify the mechanism in any given case. Occasionally the opportunity arises to study a patient with jaundice who apparently does not fit into any of the standard categories, and in whom the presence of an elevated bilirubin is compatible with good health.Constitutional hepatic dysfunction was probably first described by Gilbert and his associates in 1902. Since that time, several excellent reviews of this subject have been presented,...Bibliography1. Schiff L: Serum bilirubin in health and disease, Arch. Int. Med. 40: 800, 1927. CrossrefGoogle Scholar2. RozendaalComfortSnell HMMWAM: Slight and latent jaundice; the significance of elevated concentration of bilirubin giving an indirect van den Bergh reaction, J. A. M. A. 104: 374 (Feb. 2) 1935. CrossrefGoogle Scholar3. Comfort MW: Constitutional hepatic dysfunction, Proc. Staff Meet., Mayo Clin. 10: 57, 1935. Google Scholar4. MalloyLowenstein HTL: Hereditary jaundice in the rat, Canad. M. A. J. 42: 122-125 (Feb.) 1940. MedlineGoogle Scholar5. DameshekSinger WK: Familial non hemolytic jaundice; constitutional hepatic dysfunction with indirect van den Bergh reaction, Arch. Int. Med. 67: 259 (Feb.) 1941. CrossrefGoogle Scholar6. CurryGreenwaltTat JJTJRJ: Familial non hemolytic jaundice. Report of a case with liver biopsy, New England J. Med. 226: 909, 1942. CrossrefGoogle Scholar7. ComfortHoyne MWRM: Constitutional hepatic dysfunction: clinical study of thirty-five cases, Gastroenterology 3: 155-163 (Sept.) 1944. Google Scholar8. Comfort MW: Constitutional hepatic dysfunction, M. Clin. North America 29: 982 (July 29) 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication August 10, 1956.From the Division of Gastroenterology, Department of Medicine, Ohio State University, Columbus, Ohio.†This study was supported in part by the Comley Fund for Medical Research.Requests for reprints should be addressed to Floyd M. Beman, M.D., Division of Gastroenterology, Department of Medicine, The Ohio State University, Columbus 10, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1958Volume 48, Issue 1Page: 202-205KeywordsBilirubinResearch funding ePublished: 1 December 2008 Issue Published: 1 January 1958 PDF downloadLoading ...