2009•Shandong yiyaoRequires access

The protective role of 3′-Methoxypuerarin in hippocampal neurons against ischemia/reperfusion injury in rats.

Yajun Liu, Xiaonan Chen, Kejing Liu, Qiang Chai, LI Jing-xin, Sun Dong, Lian-Bi Chen

Abstract

Objective To investigate the protective role of 3′-Methoxypuerarin(3′-MOP) in hippocampal neurons against ischemia/reperfusion injury in rats.Method Rats were randomly divided into an ischemia/reperfusion(IR) group,an IR+3′-MOP group and a control group.Histological changes in the neurons of the hippocampal CA1 region were observed with HE staining.The apoptotic neurons in hippocampal CA1 area were counted with TUNEL staining.Result Compared with IR group,3′-MOP could increase the number of surviving neurons in hippocampal CA1 region(P0.01) and markedly reduce the number of apoptotic pyramidal neurons(P0.01)after ischemia/reperfusion injury.Conclusion 3′-Methoxypuerarin can protect the hippocampal neurons against ischemia/reperfusion injury via reducing the inhibiting apoptosis.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Hippocampal formation, TUNEL assay, Ischemia, Apoptosis, Reperfusion injury, Hippocampus, Medicine, Anesthesia