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Cerebral amyloid angiopathy as a cause of recurrent intracerebral hemorrhage.

Majid Mughal, Scott F. Allen

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Abstract

Cerebral amyloid angiopathy is a largely untreatable disease often not diagnosed until autopsy. Severe cerebral amyloid angiopathy can cause lobar cerebral hemorrhage, transient neurological symptoms, and dementia with leukoencephalopathy. Several outcome studies have suggested lower mortality and better functional recovery in lobar compared with deep hemorrhage. Recurrence of lobar hemorrhage however is relatively common. We describe a case of recurrent spontaneous intracerebral hemorrhage in a 72-year-old woman requiring surgical evacuations. A review of the literature summarizing the diagnosis and treatment of cerebral amyloid angiopathy is presented.

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Cerebral amyloid angiopathy is a largely untreatable disease often not diagnosed until autopsy. Severe cerebral amyloid angiopathy can cause lobar cerebral hemorrhage, transient neurological symptoms, and dementia with leukoencephalopathy. Several outcome studies have suggested lower mortality and better functional recovery in lobar compared with deep hemorrhage. Recurrence of lobar hemorrhage however is relatively common. We describe a case of recurrent spontaneous intracerebral hemorrhage in a 72-year-old woman requiring surgical evacuations. A review of the literature summarizing the diagnosis and treatment of cerebral amyloid angiopathy is presented.

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Available abstract

Cerebral amyloid angiopathy is a largely untreatable disease often not diagnosed until autopsy. Severe cerebral amyloid angiopathy can cause lobar cerebral hemorrhage, transient neurological symptoms, and dementia with leukoencephalopathy. Several outcome studies have suggested lower mortality and better functional recovery in lobar compared with deep hemorrhage. Recurrence of lobar hemorrhage however is relatively common. We describe a case of recurrent spontaneous intracerebral hemorrhage in a 72-year-old woman requiring surgical evacuations. A review of the literature summarizing the diagnosis and treatment of cerebral amyloid angiopathy is presented.

Key concepts: Cerebral amyloid angiopathy, Medicine, Intracerebral hemorrhage, Angiopathy, Leukoencephalopathy, Dementia, Autopsy, Amyloid (mycology)

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