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1997•TURKISH JOURNAL OF MEDICAL SCIENCESRequires access

Allele and Genotype Frequencies of the Angiotensin - Converting - Enzyme (ACE) Gene Insertion - Deletion Polymorphism in the Turkish Population

Ali Can Hatemi, Naci Çine, Tayfun Özçelık

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Abstract

We analyzed the insertion/deletion (I/D) polymorphism of the angiotensin-converting-enzyme (ACE) gene in 51 male and 55 female healthy subjects from different regions of Turkey. Amplification of genomic DNA using polymerase chain reaction yielded the genotypes II, ID and DD. Alllele frequencies were I=0.41 and D=0.59. Genotype frequencies were II= 0.179, ID = 0.462 and DD = 0.359. This study provides a foundation for ACE gene DD gentotype association studies in the Turkish population.

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What this paper is about

We analyzed the insertion/deletion (I/D) polymorphism of the angiotensin-converting-enzyme (ACE) gene in 51 male and 55 female healthy subjects from different regions of Turkey. Amplification of genomic DNA using polymerase chain reaction yielded the genotypes II, ID and DD. Alllele frequencies were I=0.41 and D=0.59. Genotype frequencies were II= 0.179, ID = 0.462 and DD = 0.359. This study provides a foundation for ACE gene DD gentotype association studies in the Turkish population.

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Available abstract

We analyzed the insertion/deletion (I/D) polymorphism of the angiotensin-converting-enzyme (ACE) gene in 51 male and 55 female healthy subjects from different regions of Turkey. Amplification of genomic DNA using polymerase chain reaction yielded the genotypes II, ID and DD. Alllele frequencies were I=0.41 and D=0.59. Genotype frequencies were II= 0.179, ID = 0.462 and DD = 0.359. This study provides a foundation for ACE gene DD gentotype association studies in the Turkish population.

Key concepts: Turkish population, Medicine, Genetics, Genotype, Allele, Gene, Polymorphism (computer science), Allele frequency

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