1982•YAKUGAKU ZASSHIOpen access

Effect of Crude Drugs on Experimental Liver Damages. II. Effect of New Sesquiterpenoid"Furanogermenone"

Johji Yamahara, Hisashi Matsuda, TOKUNOSUKE SAWADA, Hiroko Sakurai, Atsuko Matsumura, Seiji Toyama, I Suzuki

Abstract

The effect of furanogermenone was investigated on experimental liver damage induced by the administration of CCl4, d-galactosamine, ethionine, thioacetamide, phalloidin and α-amanitin. Furanogermenone suppressed the increase of serum GOT and GPT induced by CCl4, but it proved to have no significant effect on other hepatotoxins.

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Available abstract

Key concepts: Hepatotoxin, Thioacetamide, Ethionine, CCL4, Chemistry, Pharmacology, Phalloidin, Biochemistry