1988•Journal of the Japan Veterinary Medical AssociationOpen access

Changes of Dog Serum ^|^alpha;-Fetoprotein Levels in Acute Liver Injuries Induced by Hepatotoxins

Hiroshi Shibata, Hidenori Yamanaka

Abstract

Changes of serum α-fetoprotein (AFP), transaminase (GOT, GPT) and bilirubin levels after a single administration of carbon tetrachloride, galactosamine, α-naphthylisothiocyanate or ethionine were studied in dogs 5-10 months old.The serum, AFP level after these hepatotoxins administration increased in propotion to the administered dose in any case, but the extent of increase after carbon tetrachloride or galactosamine was much higher than that after α-naphthylisothiocyanate or ethionine.

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Key concepts: Hepatotoxin, Ethionine, Carbon tetrachloride, Internal medicine, Bilirubin, Transaminase, Chemistry, Endocrinology