1983•American Journal of PsychiatryRequires access
A controlled clinical trial of alprazolam for the treatment of anxiety
Karl Rickels, I Csanalosi, Paul Greisman, David Cohen, Joshua H. Werblowsky, H A Ross, H Harris
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Abstract
The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.