Evaluation of Neuropharmacological Activities of Methanolic and Aqueous Extracts of Citrus Reticulata (Rutaceae) Fruit Peels

Introduction: Herbal medicines are getting more interest because of their cost-effective, eco-friendly attributes and proper reprieve from disease condition.The present study was designed to evaluate the anxiolytic activity potentials in peels of Citrus reticulata (Family: Rutaceae) in Libya. Methods:The peel of the fruits were separated and subjected to cold extraction using 99% Methanol and hot water extraction.The extracts obtained were screened for anxiolytic activity of extracts at 1.25 to 5mg/Kg body weight concentrations and were assessed by Elevated Plus Maze.Results: The results revealed that, both extracts treated animals have shown significant anxiolytic activity.From the results it was evident that citrus peel extract of Citrus reticulata exhibited significant anxiolytic activity.Conclusion: From the results it was evident that Citrus reticulata has prominent activity in terms of parameters assessed in a dose dependent manner.