Role of transforming growth factor-β/Smad pathway and related factors in the pathogenesis of keloids
Huang Wenhua, Zhenlong Zheng, Zhehu Jin
Abstract
Huang Wenhua, Zhenlong Zheng, Zhehu Jin
Abstract
摘要: 【摘要】 转化生长因子(TGF)-β/Smad通路在瘢痕疙瘩成纤维细胞的分化和瘢痕疙瘩的疾病进展中起重要作用。在瘢痕疙瘩发病过程中,缺氧诱导因子1α、微小RNA、长链非编码RNA、激活转录因子3、炎症因子、赖氨酸氧化酶样蛋白2等是TGF-β/Smad通路常见的影响因子。本文综述瘢痕疙瘩发病机制中TGF-β/Smad通路和常见影响因子的最新研究进展。
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摘要: 【摘要】 转化生长因子(TGF)-β/Smad通路在瘢痕疙瘩成纤维细胞的分化和瘢痕疙瘩的疾病进展中起重要作用。在瘢痕疙瘩发病过程中,缺氧诱导因子1α、微小RNA、长链非编码RNA、激活转录因子3、炎症因子、赖氨酸氧化酶样蛋白2等是TGF-β/Smad通路常见的影响因子。本文综述瘢痕疙瘩发病机制中TGF-β/Smad通路和常见影响因子的最新研究进展。
Key concepts: SMAD, Transforming growth factor, Pathogenesis, Cancer research, Internal medicine, Endocrinology, Biology, Medicine