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Hodgkin’s Disease: II. Classical Hodgkin’s Disease

James A. Strauchen

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Abstract

Abstract Classical Hodgkin’s Disease (HD) is characterized by proliferation of Reed-Sternberg (RS) and Reed-Sternberg-variant cells in an inflammatory background. Although several histopathologic variants are recognized, the RS and RS-variant cells demonstrate a uniform immunophenotype, characterized by CD15 and CD30 positivity and lack of specific B or T cell antigens.

About this research paper

What this paper is about

Abstract Classical Hodgkin’s Disease (HD) is characterized by proliferation of Reed-Sternberg (RS) and Reed-Sternberg-variant cells in an inflammatory background. Although several histopathologic variants are recognized, the RS and RS-variant cells demonstrate a uniform immunophenotype, characterized by CD15 and CD30 positivity and lack of specific B or T cell antigens.

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Method / approach

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Available abstract

Abstract Classical Hodgkin’s Disease (HD) is characterized by proliferation of Reed-Sternberg (RS) and Reed-Sternberg-variant cells in an inflammatory background. Although several histopathologic variants are recognized, the RS and RS-variant cells demonstrate a uniform immunophenotype, characterized by CD15 and CD30 positivity and lack of specific B or T cell antigens.

Key concepts: CD15, Reed–Sternberg cell, CD30, Immunophenotyping, Disease, Classical Hodgkin lymphoma, Antigen, Pathology

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