The efficacy and safety of permethrin 5% vs ivermectin 1% in the treatment of uncomplicated scabies

Human scabies is an intensely pruritic skin infestation caused by the host-specific mite Sarcoptes scabiei var hominis. Scabies is a global public health problem, affecting persons of all ages, races, and socioeconomic groups. Scabies impairs the quality of life of patients and their families by the itching. Worldwide, an estimated 300 million cases occur annually. Permethrin 5% has been used widely as scabicidal drug. A new search for alternate scabicidal drugs is a need of the hour due to emerging permethrin resistance. Oral Ivermectin has been used in the management of scabies, with only a little exploration about topical Ivermectin.