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2023•Journal of BacteriologyOpen access

A Novel CovS Variant Harbored by a Colonization Strain Reduces Streptococcus pyogenes Virulence

Céline Plainvert, Isabelle Rosinski‐Chupin, Antonin Weckel, Clara Lambert, Gérald Touak, Elisabeth Sauvage, Claire Poyart, Philippe Glaser, Agnès Fouet

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Abstract

mutant strains, barely responded to environmental signals, and was less virulent than the wild-type strain. This supports the importance of the derepression of the expression of most virulence genes, via mutations that impact the phosphorylation of the regulator CovR, for favoring S. pyogenes invasive infections.

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What this paper is about

mutant strains, barely responded to environmental signals, and was less virulent than the wild-type strain. This supports the importance of the derepression of the expression of most virulence genes, via mutations that impact the phosphorylation of the regulator CovR, for favoring S. pyogenes invasive infections.

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Available abstract

mutant strains, barely responded to environmental signals, and was less virulent than the wild-type strain. This supports the importance of the derepression of the expression of most virulence genes, via mutations that impact the phosphorylation of the regulator CovR, for favoring S. pyogenes invasive infections.

Key concepts: Biology, Virulence, Streptococcus pyogenes, Mutant, Regulon, Microbiology, Gene, Genetics

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