2006•Computational Biology and ChemistryRequires access

The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises

Jeong‐Rae Kim, Kwang‐Hyun Cho

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Key concepts: Histidine kinase, Response regulator, Autophosphorylation, Two-component regulatory system, Histidine, Robustness (evolution), Component (thermodynamics), Stimulus (psychology)