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2022•Autophagy ReportsOpen access

ULK1 in autophagy: sugar it up

Sheng Yan, Jing Li

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Abstract

Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Autophagy plays a housekeeping role in maintaining cellular homeostasis and therefore can cause many human diseases if it is dysregulated. Our recent paper reported that ULK1 (unc-51 like autophagy activating kinase 1) is glycosylated at S409/S410 and further revealed the biochemical effect in stabilizing this protein.Abbreviations: CMA: chaperone-mediated autophagy; HNSCCs: head and neck squamous cell carcinomas; HPV: human papillomavirus; O-GlcNAc: O-linked β-N-acetylglucosamine; PTM: post-translational modification; ULK1: unc-51 like autophagy activating kinase 1

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What this paper is about

Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Autophagy plays a housekeeping role in maintaining cellular homeostasis and therefore can cause many human diseases if it is dysregulated. Our recent paper reported that ULK1 (unc-51 like autophagy activating kinase 1) is glycosylated at S409/S410 and further revealed the biochemical effect in stabilizing this protein.Abbreviations: CMA: chaperone-mediated autophagy; HNSCCs: head and neck squamous cell carcinomas; HPV: human papillomavirus; O-GlcNAc: O-linked β-N-acetylglucosamine; PTM: post-translational modification; ULK1: unc-51 like autophagy activating kinase 1

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Available abstract

Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Autophagy plays a housekeeping role in maintaining cellular homeostasis and therefore can cause many human diseases if it is dysregulated. Our recent paper reported that ULK1 (unc-51 like autophagy activating kinase 1) is glycosylated at S409/S410 and further revealed the biochemical effect in stabilizing this protein.Abbreviations: CMA: chaperone-mediated autophagy; HNSCCs: head and neck squamous cell carcinomas; HPV: human papillomavirus; O-GlcNAc: O-linked β-N-acetylglucosamine; PTM: post-translational modification; ULK1: unc-51 like autophagy activating kinase 1

Key concepts: Autophagy, ULK1, Sugar, Chemistry, Biology, Cell biology, Food science, Biochemistry

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