ScholarLens Back to search
2017•Int J GenetRequires access

AMPK-mTOR-ULK1/2 signaling pathway and autophagy

Su Li, Haiming Sun, Donglin Sun

Open publisher page 0 citations

Abstract

Autophagy, also called typeⅡcell death, is a process in which cells use lysosome to degrade damaged organelles and macromolecules. It has been found that autophagy is related to many diseases, including Alzheimers, cardiomyopathy and tumor. AMPK-mTOR-ULK1/2 signaling pathway plays an important role in regulating autophagy, and studies of this pathway may further clarify mechanism of autophagy, and provide a potential therapeutic target of autophagy-based diseases. In this paper, we review the functions of each component and regulating mechanisms. Key words: Autophagy; AMPK; mTOR

About this research paper

What this paper is about

Autophagy, also called typeⅡcell death, is a process in which cells use lysosome to degrade damaged organelles and macromolecules. It has been found that autophagy is related to many diseases, including Alzheimers, cardiomyopathy and tumor. AMPK-mTOR-ULK1/2 signaling pathway plays an important role in regulating autophagy, and studies of this pathway may further clarify mechanism of autophagy, and provide a potential therapeutic target of autophagy-based diseases. In this paper, we review the functions of each component and regulating mechanisms. Key words: Autophagy; AMPK; mTOR

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Autophagy, also called typeⅡcell death, is a process in which cells use lysosome to degrade damaged organelles and macromolecules. It has been found that autophagy is related to many diseases, including Alzheimers, cardiomyopathy and tumor. AMPK-mTOR-ULK1/2 signaling pathway plays an important role in regulating autophagy, and studies of this pathway may further clarify mechanism of autophagy, and provide a potential therapeutic target of autophagy-based diseases. In this paper, we review the functions of each component and regulating mechanisms. Key words: Autophagy; AMPK; mTOR

Key concepts: Autophagy, ULK1, AMPK, PI3K/AKT/mTOR pathway, Cell biology, Lysosome, mTORC2, Signal transduction

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
AMPK-mTOR-ULK1/2 signaling pathway and autophagy — Research Paper | ScholarLens