Thioether analogues of the pituitary neuropeptide oxytocin via thiol–ene macrocyclisation of unprotected peptides
Mark D. Nolan, Conor Shine, Eoin M. Scanlan, Rita Petracca
Abstract
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Mark D. Nolan, Conor Shine, Eoin M. Scanlan, Rita Petracca
Abstract
Open-access reader
thiol-ene click chemistry. Furthermore, this methodology is applied to the efficient synthesis of analogues of the neuropeptide oxytocin and in a highly efficient route to the clinical therapeutic carbetocin.
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thiol-ene click chemistry. Furthermore, this methodology is applied to the efficient synthesis of analogues of the neuropeptide oxytocin and in a highly efficient route to the clinical therapeutic carbetocin.
Key concepts: Thioether, Chemistry, Disulfide bond, Thiol, Oxytocin, Neuropeptide, Combinatorial chemistry, Peptide