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1999•Unpublished venueRequires access

Protection for the Thiol Group

Theodora W. Greene, Peter G. M. Wuts

Open publisher page 9 citations

Abstract

Protection for the thiol group is important in many areas of organic research, particularly in peptide and protein syntheses. The synthesis of coenzyme A requires the use of thiol protective groups. A free –SH group can be protected as a thioether or a thioester, or oxidized to a symmetrical disulfide, from which it is regenerated by reduction. This chapter discusses some synthetically useful thiol protective groups. Some of the more useful groups are included in Reactivity Chart 7 (Chapter 10).

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What this paper is about

Protection for the thiol group is important in many areas of organic research, particularly in peptide and protein syntheses. The synthesis of coenzyme A requires the use of thiol protective groups. A free –SH group can be protected as a thioether or a thioester, or oxidized to a symmetrical disulfide, from which it is regenerated by reduction. This chapter discusses some synthetically useful thiol protective groups. Some of the more useful groups are included in Reactivity Chart 7 (Chapter 10).

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Available abstract

Protection for the thiol group is important in many areas of organic research, particularly in peptide and protein syntheses. The synthesis of coenzyme A requires the use of thiol protective groups. A free –SH group can be protected as a thioether or a thioester, or oxidized to a symmetrical disulfide, from which it is regenerated by reduction. This chapter discusses some synthetically useful thiol protective groups. Some of the more useful groups are included in Reactivity Chart 7 (Chapter 10).

Key concepts: Thiol, Group (periodic table), Computer science, Chemistry, Biochemistry, Organic chemistry

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